Endocrine Abstracts

The present study was conducted to investigate the signaling pathway involved in betanin against noise and scrotal hyperthermia and to clarify whether it affects oxidative stress, apoptosis and inflammation in testis of rats. Scrotal hyperthermia was induced by heat exposure of rat testicular for 43ºC for 15 min (3 times per weeks for 14 days). Noise induction was done following exposure of rats with 100 decibel noise level for 14 day and 8 h daily similar to real conditi...

Background: Hypoparathyroidism is a rare endocrine disorder characterised by low serum calcium with inappropriately low parathyroid hormone (PTH) levels. Calcium and vitamin D analogues have traditionally been the mainstay of treatment. However, these treatments may cause complications and may not fully address the well-being of this patient group. This study evaluates the current management of hypoparathyroidism in a large UK teaching hospital compared against current Europea...

Introduction: Primary hyperparathyroidism affects 1% of the world’s population, with majority of cases due to benign parathyroid adenomas. Parathyroid cancer is a rare cause.Case report: This case report describes a 53-year-old lady presenting with nonspecific bone pains, whose initial workup revealed mild hypercalcemia and MRI lumbosacral spine suggestive of multiple myeloma. Subsequent work up, including two bone marrow examinations and serum prot...

Background and aims: Proper assessment of long-term safety of newer antidiabetic agents (ADAs) is of prime importance as diabetes is a chronic disease requiring life-long management. The purpose of this analysis was to assess the safety of vildagliptin as monotherapy or as an add-on therapy to already existing ADAs (vildagliptin group) compared to non-vildagliptin group.Materials and methods: Nine hundred and eighty-three patients in vildagliptin group a...

Ectopic parathyroid glands arise from aberrant migration during early stage of development. Lack of successful identification leads to failed parathyroid surgery and persistent hyperparathyroidism.Case History: A 57-year-old lady presented with abdominal discomfort and diffuse bone pain. Her corrected serum calcium was raised at 2.81mmol/l, reduced serum phosphate with an inappropriate intact PTH concentration of 10.5 pmol/l. Initial, vi...

Background and Purpose: AHC (X-linked adrenal hypoplasia congenita) is a rare cause of adrenal insufficiency due to mutations in NROB1 gene. It traditionally causes hypogonadotropic hypogonadism. Rare cases of central precocious puberty due to NROB1 mutation has been reported so far. We present two interesting cases of NROB1 mutation from a same family with different presentations. This is first case report of NROB1 mutation from Pakistan. Case Report: I...

Background: Steroid cell tumour of ovaries comes under sex cord stromal tumour that accounts less than 0.1% of all ovarian tumour. Majority are benign in childhood age group. It may produce steroids and testosterone resulting in virilisation and Cushing’s syndrome. Histology remains the gold standard for diagnosis of NOS. The gross appearance of NOS generally is well circumscribed, solid and noncalcifed with a lobulated appearance Till date only 10 cases has been reported...

Introduction: Prolactinoma is the most common type of pituitary adenoma, but it still presents difficulties in management especially in women who present some particularities hence the interest of our study.1Material and method: This is a retrospective, descriptive study including 14 patients, hospitalized in the Endocrinology-Diabetology-Nutrition Department at CHU-Mohammed-VI-Oujda, between 2016–2022. The statistical analysis was perfor...

Lung cancer is globally the biggest cause of cancer-related death, resulting in almost 1.6 million deaths per year. Neuroendocrine tumours amount to up to 25% of all lung cancer diagnoses. Pulmonary neuroendocrine tumours lie on a biological continuum of malignant behaviour, which range from the malignant, but relatively indolent, typical carcinoid tumours to small cell lung carcinoma- the most aggressive of the primary neuroendocrine lung tumours. Although small cell carcinom...

IntroductionDiabetic peripheral neuropathy is a common degenerative complication of diabetes. The aim of our work is to focus on the prevalence of this complication in relation to the imbalance of diabetes in type 2 diabetics (T2DM).Materials and methodsThis is a retrospective study, including 202 type 2 diabetic patients hospitalized in an Endocrinology-Diabetology department, over a 6-year time period. All ...